Yen

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Possible Answers: ACHE, URGE, ITCH, WISH, DESIRE, THIRST, YEARNING, INTENSEYEARNING, YEARNINGFEELING.

Last seen on: –Wall Street Journal Crossword – Feb 27 2019 – Taking Sides
Newsday.com Crossword – Sep 14 2018
Wall Street Journal Crossword – Jun 16 2018 – Forefathers
-Universal Crossword December 5 2017
-Eugene Sheffer – King Feature Syndicate Crossword – Dec 2 2017
-Metro Crossword November 25 2017

Random information on the term “ACHE”:

An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).

Acetylcholinesterase inhibitors:

Some major effects of cholinesterase inhibitors:

Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.

When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).

ACHE on Wikipedia

Random information on the term “URGE”:

Ellen Victoria Futter (born September 21, 1949) is president of the American Museum of Natural History. She previously served as president of Barnard College for 13 years.

Futter was born in New York City and attended high school in Port Washington, New York. She spent two years at the University of Wisconsin–Madison before transferring to Barnard College, where she graduated Phi Beta Kappa magna cum laude in 1971. She was elected as a student representative to the Barnard’s board of trustees in 1971 and was subsequently elected to full membership to complete the term of Arthur Goldberg, former Associate Justice of the Supreme Court of the United States. Futter earned her J.D. from Columbia Law School in 1974.


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Futter began her career as an associate at the Wall Street law firm of Milbank, Tweed, Hadley & McCloy, where she practiced corporate law. In 1980, Futter took a leave of absence from Milbank, Tweed to serve as Barnard’s acting president for one year. At the end of that period, she was appointed president of the college; at the time, she was the youngest president of any college in the United States. She served as president until 1993, when she joined the American Museum of Natural History.

URGE on Wikipedia

Random information on the term “ITCH”:

c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They also play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. It has been suggested that this signaling pathway contributes to inflammatory responses in mammals and insects.[citation needed]

The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). Each gene is expressed as either 46 kDa or 55 kDa protein kinases, depending upon how the 3′ coding region of the corresponding mRNA is processed. There have been no functional differences documented between the 46 kDa and the 55 kDa isoform, however, a second form of alternative splicing occurs within transcripts of JNK1 and JNK2, yielding JNK1-α, JNK2-α and JNK1-β and JNK2-β. Differences in interactions with protein substrates arise because of the mutually exclusive utilization of two exons within the kinase domain.

ITCH on Wikipedia

Random information on the term “WISH”:

Wish is the ninth studio album by British alternative rock band The Cure, released on 21 April 1992 through record label Fiction in the UK and Elektra in the US.

The record is the final studio album featuring Boris Williams and the first featuring Perry Bamonte, as well as being the last album featuring Porl Thompson for sixteen years.

Whilst retaining the sound and mood of Disintegration (1989) on some tracks, Wish often found the band moving into more of a dream pop direction.[citation needed]

The album’s lead single was “High”, released on 16 March 1992. The single peaked at number eight in the UK Singles Chart, forty-two in the US Billboard Hot 100 and number one on the Billboard Modern Rock Tracks. The album’s second single, “Friday I’m in Love”, released on 11 May 1992, became one of the band’s most popular songs – reaching number six in the UK Singles Chart and number eighteen in the Billboard Hot 100, and number one in the Modern Rock Tracks. The final single was for “A Letter to Elise”, going at number twenty-eight in the UK and 2 in the Modern Rock Tracks.

WISH on Wikipedia