This time we are looking on the crossword clue for: Long.
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Possible Answers: ACHE, YEN, ITCH, PINE, YEARN, ASPIRE, DESIRE, HANKER.
Last seen on: –The Atlantic Sunday, 7 April 2024 Crossword Answers
–The Atlantic Thursday, 4 April 2024 Crossword Answers
–Eugene Sheffer – King Feature Syndicate Crossword – Mar 30 2024
–NY Times Crossword 7 Mar 24, Thursday
–NY Times Crossword 25 Feb 24, Sunday
–Daily Boston Globe Crossword Sunday, 23 April 2023
–NY Times Crossword 4 Feb 23, Saturday
–Wall Street Journal Crossword – February 24 2022 – Let Your Hare Down
–LA Times Crossword 18 Jul 21, Sunday
–Eugene Sheffer – King Feature Syndicate Crossword – Dec 11 2020
–NY Times Crossword 6 Dec 20, Sunday
–Wall Street Journal Crossword – August 09 2020 – B-Listers
–NY Times Crossword 29 Feb 20, Saturday
–Eugene Sheffer – King Feature Syndicate Crossword – Jun 24 2019
–New York Times Crossword – Mar 14 2019
–The Telegraph – Quick Crossword – July 18 2018
-Mirror Cryptic Crossword November 20 2017
Random information on the term “ACHE”:
An acetylcholinesterase inhibitor (often abbreviated AChEI) or anti-cholinesterase is a chemical or a drug that inhibits the acetylcholinesterase enzyme from breaking down acetylcholine, thereby increasing both the level and duration of action of the neurotransmitter acetylcholine. Acetylcholinesterase inhibitors are classified as reversible, irreversible, or quasi-irreversible (also called pseudo-irreversible).
Acetylcholinesterase inhibitors:
Some major effects of cholinesterase inhibitors:
Administration of reversible cholinoesterase inhibitors is contraindicated with those that have urinary retention due to obstruction.
When used in the central nervous system to alleviate neurological symptoms, such as rivastigmine in Alzheimer’s disease, all cholinesterase inhibitors require doses to be increased gradually over several weeks, and this is usually referred to as the titration phase. Many other types drug treatments may require a titration or stepping up phase. This strategy is used to build tolerance to adverse events or to reach a desired clinical effect. This also prevents accidental overdose and is therefore recommended when initiating treatment with drugs that are extremely potent and/or toxic (drugs with a low therapeutic index).
Random information on the term “YEN”:
₳ ฿ ₵ ¢ ₡ ₢ $ ₫ ₯ ֏ ₠ € ƒ ₣ ₲ ₴ ₭ ₺ ₾ ℳ ₥ ₦ ₧ ₱ ₰ £ ៛ ₽ ₹ ₨ ₪ ৳ ₸ ₮ ₩ ¥
The Yen sign (¥) is a currency sign used by the Chinese yuan (CNY) and the Japanese yen (JPY) currencies. This monetary symbol resembles a Latin letter Y with a double stroke. The base unit of both currencies shared the same Chinese character/Kanji (traditional Chinese: 圓; simplified Chinese: 圆; Japanese Shinjitai: 円) that means “circle”. It is pronounced yuán in Mandarin Chinese and en in Standard Japanese. In mainland China, the Chinese character is more frequently written in everyday situations using the simpler character 元, which has the same pronunciation as the formal financial character 圓 in Mandarin (but not in Japanese and in some Chinese varieties). The symbol is usually placed before the value it represents, for example 20.
In the Japanese-language locales of Microsoft operating systems, the yen sign in code page 932 character encoding has the same byte value as the backslash in ASCII. It is also used wherever a backslash is used, such as the directory separator character and the general escape character, essentially making it a backslash with the appearance of a yen sign, a peculiarity that stems from JIS X 0201.
Random information on the term “ITCH”:
c-Jun N-terminal kinases (JNKs), were originally identified as kinases that bind and phosphorylate c-Jun on Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress stimuli, such as cytokines, ultraviolet irradiation, heat shock, and osmotic shock. They also play a role in T cell differentiation and the cellular apoptosis pathway. Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinases, MKK4 and MKK7 and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases. It has been suggested that this signaling pathway contributes to inflammatory responses in mammals and insects.[citation needed]
The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). Each gene is expressed as either 46 kDa or 55 kDa protein kinases, depending upon how the 3′ coding region of the corresponding mRNA is processed. There have been no functional differences documented between the 46 kDa and the 55 kDa isoform, however, a second form of alternative splicing occurs within transcripts of JNK1 and JNK2, yielding JNK1-α, JNK2-α and JNK1-β and JNK2-β. Differences in interactions with protein substrates arise because of the mutually exclusive utilization of two exons within the kinase domain.
Random information on the term “PINE”:
Alpine is a free software email client developed at the University of Washington.
Alpine is a rewrite of the Pine Message System that adds support for Unicode and other features. Alpine is meant to be suitable for both inexperienced email users and the most demanding of power users. Alpine can be learned by exploration and the use of context-sensitive help. The user interface can be customized.
Alpine shares many common features of console applications, like a rich set of shortcut keys, using keyboard instead of mouse to do all navigation and operation. In fact, all operations in Alpine have corresponding shortcut keys.
Unlike other console applications targeting developers and experienced users, which often require users to edit a configuration file, Alpine lets users change most configuration options within the software. This makes alpine one of the most easy to learn console-based email clients.
Alpine supports IMAP, POP, SMTP, NNTP and LDAP protocol natively. Although it does not support composing HTML email, it can display emails that only have HTML content as text. Alpine can read and write to folders in several formats, including Maildir, mbox, the mh format used by the mh message handling system, mbx, and mix.