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Possible Answers: APB.
Last seen on: The Washington Post Crossword – Aug 15 2018
Random information on the term “PBA”:
The Philippine Basketball Association (PBA) is a men’s professional basketball league in the Philippines composed of twelve company-branded franchised teams. It is the first professional basketball league in Asia and is the second oldest continuously existing in the world after the NBA.[1] The league’s regulations are a hybrid of rules from the NBA and FIBA.
The league played its first game at the Araneta Coliseum in Quezon City on April 9, 1975.[2] Its main offices are located along Eulogio Rodriguez Jr. Avenue (C-5 road), Eastwood City, Bagumbayan, Quezon City.
The Philippine Basketball Association was founded when nine teams left the now-defunct Manila Industrial and Commercial Athletic Association (MICAA), which was tightly controlled by the Basketball Association of the Philippines (BAP), the FIBA-recognized national association at the time.[3] With the BAP controlling the MICAA, the league was de jure amateur, as players were only paid allowances. This is much like what was done in other countries to circumvent the amateur requirement and to play in FIBA-sanctioned tournaments such as the Olympics. MICAA team owners were not pleased with how BAP, then led by Gonzalo “Lito” Puyat are taking away their players to join the national team without consulting them first.[4] The teams that bolted away from the MICAA are the Carrier Weathermakers, Crispa Redmanizers, Mariwasa-Noritake Porcelainmakers, Presto Ice Cream, Royal Tru-Orange, Seven-Up Uncolas, Tanduay Distillery, Toyota Comets and the U/Tex Weavers. Leopoldo Prieto, the coach for the Philippines at the 1956 Melbourne Olympics, was appointed as the first commissioner and Emerson Coseteng of Mariwasa-Noritake was chosen as the first president of the league’s Board of Governors.[5] The first game of the league was held at the Araneta Coliseum on April 9, 1975, featuring Mariwasa-Noritake and Concepcion Carrier.
Random information on the term “APB”:
6-APB (6-(2-aminopropyl)benzofuran) is an empathogenic psychoactive compound of the substituted benzofuran, substituted amphetamine and substituted phenethylamine classes. 6-APB and other compounds are sometimes informally called “Benzofury” in newspaper reports. It is similar in structure to MDA, but differs in that the 3,4-methylenedioxyphenyl ring system has been replaced with a benzofuran ring. 6-APB is also the unsaturated benzofuran derivative of 6-APDB. It may appear as a tan grainy powder. While the drug never became particularly popular, it briefly entered the rave and underground clubbing scene in the UK before its sale and import were banned. It falls under the category of research chemicals, sometimes called “legal highs.” Because 6-APB and other substituted benzofurans have not been explicitly outlawed in some countries, they are often technically legal, contributing to their popularity.
6-APB is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with Ki values of 117, 150, and 2698 nM for the norepinephrine transporter (NET), dopamine transporter (DAT), and serotonin transporter (SERT), respectively.[1] In addition, 6-APB not only blocks the reuptake of these monoamine neurotransmitters but is also a releasing agent of them; that is, it is a serotonin-norepinephrine-dopamine releasing agent (SNDRA).[2] In addition to actions at the monoamine transporters, 6-APB is a potent full agonist of the serotonin 5-HT2B receptor (Ki = 3.7 nM),[1][1] with higher affinity for this target than any other site.[3] Moreover, unlike MDMA, 6-APB shows 100-fold selectivity for the 5-HT2B receptor over the 5-HT2A and 5-HT2C receptors.[3][4] It is notably both more potent and more selective as an agonist of the 5-HT2B receptor than the reference 5-HT2B receptor agonist, BW-723C86, which is commonly used for research into the 5-HT2B receptor.[citation needed] Aside from the 5-HT2B receptor, 6-APB has also been found to bind with high affinity to the α2C-adrenergic receptor subtype (Ki = 45 nM), although the clinical significance of this action is unknown.[1] 6-APB showed little other affinity at a wide selection of other sites.[1]