Place that sounds like 21-Across' opposite

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Possible Answers:

INN.

Last seen on: USA Today Crossword – Sep 24 2022

Random information on the term “INN”:

Mandate

The World Health Organization has a constitutional mandate to “develop, establish and promote international standards with respect to biological, pharmaceutical and similar products”.

The World Health Organization collaborates closely with INN experts and national nomenclature committees to select a single name of worldwide acceptability for each active substance that is to be marketed as a pharmaceutical. To avoid confusion, which could jeopardize the safety of patients, trade-marks should neither be derived from INNs nor contain common stems used in INNs.

WHO

An international nonproprietary name (INN) is an official generic and nonproprietary name given to a pharmaceutical drug or an active ingredient. INNs are intended to make communication more precise by providing a unique standard name for each active ingredient, to avoid prescribing errors. The INN system has been coordinated by the World Health Organization (WHO) since 1953.

INN on Wikipedia