Bar staple

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Possible Answers: ICE, RYE, SODA, OLIVE, GIN, STOOL, TONIC, KARAOKE.

Last seen on: –Wall Street Journal Crossword – September 19 2022 – Pirate Program
Wall Street Journal Crossword – May 26 2022 – Going Downhill Fast
LA Times Crossword 31 Aug 21, Tuesday
LA Times Crossword 15 Jan 21, Friday
The Washington Post Crossword – Oct 2 2020
Universal Crossword – Aug 7 2020
Thomas Joseph – King Feature Syndicate Crossword – Jan 23 2020

Random information on the term “ICE”:

1BMQ, 1IBC, 1ICE, 1RWK, 1RWM, 1RWN, 1RWO, 1RWP, 1RWV, 1RWW, 1RWX, 1SC1, 1SC3, 1SC4, 2FQQ, 2H48, 2H4W, 2H4Y, 2H51, 2H54, 2HBQ, 2HBR, 2HBY, 2HBZ, 3D6F, 3D6H, 3D6M, 3E4C, 3NS7, 5FNA

834

12362

ENSG00000137752

ENSMUSG00000025888

P29466

P29452

NM_033294
NM_033295

NM_009807

NP_150636
NP_150637

NP_033937.2
NP_033937

Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.

ICE on Wikipedia

Random information on the term “RYE”:

Rye is a small town in the non-metropolitan county of East Sussex, within the historic County of Sussex, England, which stands approximately two miles from the open sea and is at the confluence of three rivers: the Rother, the Tillingham and the Brede. In medieval times, however, as an important member of the Cinque Ports confederation, it was at the head of an embayment of the English Channel and almost entirely surrounded by the sea.

Rye is officially a civil parish but with its historic roots has the status of a town; at the 2011 census it had a population of 4773. During its history its association with the sea has included providing ships for the service of the King in time of war, and being involved with smuggling gangs of the 18th and 19th centuries such as the notorious Hawkhurst Gang who used its inns such as The Mermaid Inn and The Olde Bell Inn, connected by secret passageway.

Those historic roots and its charm make it a tourist destination, and much of its economy is based on that: there are a number of hotels, guest houses, B&Bs, tea rooms and restaurants, as well as other attractions, catering for the visitor. There is a small fishing fleet, and Rye Harbour has facilities for yachts and other vessels.

RYE on Wikipedia

Random information on the term “SODA”:

Sodium carbonate (also known as washing soda, soda ash and soda crystals, and in the monohydrate form as crystal carbonate), Na2CO3, is the water-soluble sodium salt of carbonic acid.

It most commonly occurs as a crystalline decahydrate, which readily effloresces to form a white powder, the monohydrate. Pure sodium carbonate is a white, odorless powder that is hygroscopic (absorbs moisture from the air). It has a strongly alkaline taste, and forms a moderately basic solution in water. Sodium carbonate is well known domestically for its everyday use as a water softener. Historically it was extracted from the ashes of plants growing in sodium-rich soils, such as vegetation from the Middle East, kelp from Scotland and seaweed from Spain. Because the ashes of these sodium-rich plants were noticeably different from ashes of timber (used to create potash), they became known as “soda ash”. It is synthetically produced in large quantities from salt (sodium chloride) and limestone by a method known as the Solvay process.

SODA on Wikipedia

Random information on the term “GIN”:

The 20th Century is a cocktail created in 1937 by a British bartender named C.A. Tuck, and named in honor of the celebrated Twentieth Century Limited train which ran between New York City and Chicago from 1902 until 1967. The recipe was first published in 1937 in the Café Royal Cocktail Book by William J Tarling, President of the United Kingdom Bartenders’ Guild and head bartender at the Café Royal.

Shake in an iced cocktail shaker, and strain into a cocktail glass. Garnish with a lemon twist.

GIN on Wikipedia