Brooks who directed “Blazing Saddles”

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Possible Answers:

MEL.

Last seen on: NY Times Crossword 16 Feb 21, Tuesday

Random information on the term “MEL”:

The mouse-derived erythroleukemia cell line F4N (MEL) is an aneuploid cell line, comes from mouse inbred strain DBA/2. It was established in 1977. Eight percent of the total number of cells in culture undergo spontaneous apoptosis.

MEL on Wikipedia